As of July 2016, I work for St. Jude Children's Research Hospital. Before then, I worked at the University of Washington, at the Institute for Health Metrics and Evaluation.
I have ongoing interests in sustainable economic development, reputation currencies, and data visualization. If you have ideas, suggestions, or questions, please contact me at s i o s o n e l -a t- g m a i l . c o m.
- PeCan Data Portal: PeCan provides interactive visualizations of pediatric cancer mutations across various projects at St. Jude Children's Research Hospital and its collaborators.
- Tatag: Tatag is a data-driven funding and payment platform.
- Mortality Visualization: The final estimates of under-five and adult mortality rates, together with crude death rates due to HIV/AIDS, were used as entry parameters to a new relational model life table system.
- Causes of Death (CoD) Visualization: Where do we have the best data on different health conditions? For any age group, see where various data sources have placed trends in causes of death over time. You can examine more than 200 causes in both adjusted and pre-adjusted numbers, rates, and percentages for 188 countries.
- TraceEval: an open accounting and reputation framework. I have prototyped various components such as NPX, with a smartphone UI design and an SMS-compatible API. I have also drafted an Internet-enabled payment protocol
which is implemented in NPX.
- Flora: This is an agent-based simulation testbed for testing the potential impact of sociotechnical proposals on population well-being. There is a related paper published in JASSS, which I presented at the ESSA 2012 summer school.
- Mostly completed projects which I might blog about later:
- (work) Automated tool for auditing archive completeness. This tool mines text in code files to determine the relationship between data files and the code that inputs or outputs them. It provides a simple visualization of file dependencies, presented
in a tree structure.
- (graduate paper) Survey of MultiModal Mobile Interfaces
- (graduate paper) Survey of Methods for Determining Online Review helpfulness (lexical features were found to be a good predictor across applicable methods)
- (work) Statistical analysis of process chromatography performance and diagnostics, with simulation of underlying separation mechanics to explain observed trends
Flora: A Testbed for Evaluating the Potential Impact of Proposed Systems on Population Wellbeing
Journal of Artificial Societies and Social Simulations
June 29, 2012
- Authors: Edgar Sioson
- Description: We present Flora, a testbed that supports multidimensional fitness and resource modeling. Its main features are evaluation metrics related to population wellbeing, scalable representation of resource diversity, and composability of sociotechnical test scenarios through the TDI framework. We ran simulations to illustrate Flora's use in modeling the effects of using information infrastructures with different component systems. We analyzed the impact of hoarders in the absence of accounting systems, compared the performance of different decentralized currency systems in terms of accounting design features, and modeled the potential impact of reputation systems in deterring detrimental socioeconomic behavior. Among findings were the importance of having resource diversity as well as resources that each could target different fitness dimension needs; the inherent robustness of accounting systems that allow organizations to set budgets independently of centrally issued currency; and the greater effectiveness of buyer-screening compared to seller-screening as a means for influencing malevolent socioeconomic actors.
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
- Nature Genetics July 3, 2017
- Authors: Yu Liu, John Easton, et. al.
- Description: Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute lymphoblastic leukemia (T-ALL), but detailed genome-wide sequencing of large T-ALL cohorts has not been carried out. Using integrated genomic analysis of 264 T-ALL cases, we identified 106 putative driver genes, half of which had not previously been described in childhood T-ALL (for example, CCND3, CTCF, MYB, SMARCA4, ZFP36L2 and MYCN). We describe new mechanisms of coding and noncoding alteration and identify ten recurrently altered pathways, with associations between mutated genes and pathways, and stage or subtype of T-ALL. For example, NRAS/FLT3 mutations were associated with immature T-ALL, JAK3/STAT5B mutations in HOXA1 deregulated ALL, PTPN2 mutations in TLX1 deregulated T-ALL, and PIK3R1/PTEN mutations in TAL1 deregulated ALL, which suggests that different signaling pathways have distinct roles according to maturational stage. This genomic landscape provides a logical framework for the development of faithful genetic models and new therapeutic approaches.
Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
- The Lancet December 17, 2014
- Authors: GBD 2013 Mortality and Causes of Death Collaborators
- Description: Up-to-date evidence on levels and trends for age-sex-specific all-cause and cause-specific mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries.